SCHEMBL20150384

SCHEMBL20150384

Cc1cccc(-c2ccc3c4ccccc4n(-c4ccc(C#N)cc4-c4nc(C)nc(C)n4)c3c2)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 1/20 0.37
ELANE P08246 2/20 0.35
F2 P00734 1/20 0.34
PLAU P00749 1/20 0.34
CTRB1 P17538 1/20 0.34
MAPK14 Q16539 1/20 0.34
ADORA2A P29274 1/20 0.34
ADORA1 P30542 1/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
GABRA1 P14867 1/20 0.33
GABRG2 P18507 1/20 0.33
GABRB3 P28472 1/20 0.33
GABRA5 P31644 1/20 0.33
GABRA3 P34903 1/20 0.33
GABRA2 P47869 1/20 0.33
KDM4A O75164 1/20 0.33
KDM5B Q9UGL1 1/20 0.33
ALDH1A3 P47895 1/20 0.33
ALDH1A1 P00352 4/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20150387 0.96 MAPK14 (0.36) PTGER4ELANEMAPK14ADORA2AADORA1
SCHEMBL20156170 0.94 CYP1A2 (0.38) PTGER4ADORA2AGABRA1GABRG2GABRB3
SCHEMBL20156150 0.93 PTGER4 (0.36) PTGER4ELANEGABRA1GABRG2GABRB3
SCHEMBL20150380 0.93 PTGER4 (0.37) PTGER4GABRA1GABRG2GABRB3GABRA5
SCHEMBL21089873 0.92 CYP1A2 (0.39) PTGER4ELANEF2PLAUCTRB1
SCHEMBL20114546 0.92 PTGER4 (0.37) PTGER4ELANEF2PLAUCTRB1
SCHEMBL20150415 0.92 PTGER4 (0.36) PTGER4ELANEADORA2AADORA1GABRA1
SCHEMBL20156218 0.92 PTGER4 (0.39) PTGER4ELANEGABRA1GABRG2GABRB3
SCHEMBL20114694 0.91 PTGER4 (0.38) PTGER4ELANEGABRA1GABRG2GABRB3
SCHEMBL20114584 0.90 PTGER4 (0.36) PTGER4ELANEGABRA1GABRG2GABRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10421746-B2 Organic molecules, especially for use in organic optoelectronic devices CYNORA GMBH (DE) 2019-09-24 US disclosed
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-17 US disclosed
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES OR10J3, EPCAM, F12 PTGER4 1809/4885ELANE 3607/4885F2 28/4885
US-10421746-B2 Organic molecules, especially for use in organic optoelectronic devices OR10J3, EPCAM, F12 PTGER4 1809/4885ELANE 3607/4885F2 28/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.