SCHEMBL20150387

SCHEMBL20150387

Cc1cccc(-c2ccc3c4ccc(-c5cccc(C)c5)cc4n(-c4ccc(C#N)cc4-c4nc(C)nc(C)n4)c3c2)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 1/20 0.36
CYP11B1 P15538 1/20 0.36
CYP11B2 P19099 1/20 0.36
KDM4A O75164 1/20 0.35
KDM5B Q9UGL1 1/20 0.35
ELANE P08246 1/20 0.35
KDM1A O60341 1/20 0.34
AR P10275 1/20 0.34
ADORA2A P29274 1/20 0.34
ADORA1 P30542 1/20 0.34
ALDH1A1 P00352 3/20 0.34
CYP1A2 P05177 3/20 0.34
LMNA P02545 2/20 0.34
TP53 P04637 2/20 0.34
CYP2C9 P11712 2/20 0.34
TSHR P16473 2/20 0.34
HSD17B10 Q99714 2/20 0.34
KDM4E B2RXH2 1/20 0.34
HPGD P15428 1/20 0.34
MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20150384 0.96 PTGER4 (0.37) MAPK14CYP11B1CYP11B2KDM4AKDM5B
SCHEMBL20114586 0.94 CLK4 (0.38) ARALDH1A1CYP1A2LMNACYP2C9
SCHEMBL20114568 0.92 MAPK14 (0.36) MAPK14CYP11B1CYP11B2KDM4AKDM5B
SCHEMBL20150394 0.91 CHEK1 (0.34) CYP11B1CYP11B2KDM5BPTGER4GRM2
SCHEMBL20114574 0.91 GABRA1 (0.39) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL20150391 0.90 CHEK1 (0.36) CYP11B1CYP11B2KDM1AALDH1A1KDM4E
SCHEMBL20114587 0.90 CHEK1 (0.40) CYP11B1CYP11B2PTGER4GRM2CHEK1
SCHEMBL20156170 0.90 CYP1A2 (0.38) ADORA2AALDH1A1CYP1A2LMNATP53
SCHEMBL20150412 0.89 CASP3 (0.35) CYP11B1CYP11B2ALDH1A1CYP1A2LMNA
SCHEMBL20156150 0.89 PTGER4 (0.36) KDM5BELANEPTGER4GRM2GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10421746-B2 Organic molecules, especially for use in organic optoelectronic devices CYNORA GMBH (DE) 2019-09-24 US disclosed
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-17 US disclosed
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES OR10J3, EPCAM, F12 MAPK14 3460/4885CYP11B1 1765/4885CYP11B2 1259/4885
US-10421746-B2 Organic molecules, especially for use in organic optoelectronic devices OR10J3, EPCAM, F12 MAPK14 3460/4885CYP11B1 1765/4885CYP11B2 1259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.