Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13138972 | 0.85 | HCRTR1 (0.50) | HCRTR1HCRTR2MAPTSMN1; SMN2TSHR | |
| SCHEMBL13139051 | 0.82 | HCRTR1 (0.47) | HCRTR1HCRTR2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13138975 | 0.81 | HCRTR1 (0.50) | HCRTR1HCRTR2MAPTSMN1; SMN2TSHR | |
| SCHEMBL13138950 | 0.81 | HCRTR1 (0.43) | HCRTR1HCRTR2MAPTSMN1; SMN2TSHR | |
| SCHEMBL13138945 | 0.80 | HCRTR1 (0.45) | HCRTR1HCRTR2MAPTSMN1; SMN2TSHR | |
| SCHEMBL2013196 | 0.80 | HCRTR1 (0.42) | HCRTR1HCRTR2MAPTSMN1; SMN2TSHR | |
| SCHEMBL13139031 | 0.80 | HCRTR1 (0.57) | HCRTR1HCRTR2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13139038 | 0.80 | HCRTR1 (0.48) | HCRTR1HCRTR2MAPTSMN1; SMN2TSHR | |
| SCHEMBL13139073 | 0.79 | HCRTR1 (0.53) | HCRTR1HCRTR2MAPTSMN1; SMN2LMNA | |
| SCHEMBL2012684 | 0.79 | HCRTR1 (0.42) | HCRTR1HCRTR2MAPTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |