Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012684 | 0.90 | HCRTR1 (0.42) | HCRTR1HCRTR2SMN1; SMN2TSHRPDE10A | |
| SCHEMBL13138972 | 0.87 | HCRTR1 (0.50) | HCRTR1HCRTR2SMN1; SMN2TSHRPDE10A | |
| SCHEMBL2014285 | 0.84 | EPHX2 (0.45) | HCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL13138950 | 0.82 | HCRTR1 (0.43) | HCRTR1HCRTR2SMN1; SMN2TSHRPDE10A | |
| SCHEMBL13138975 | 0.82 | HCRTR1 (0.50) | HCRTR1HCRTR2SMN1; SMN2TSHRRECQL | |
| SCHEMBL2014681 | 0.81 | HCRTR1 (0.43) | HCRTR1HCRTR2SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2014812 | 0.81 | HCRTR1 (0.43) | HCRTR1HCRTR2SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL13139051 | 0.81 | HCRTR1 (0.47) | HCRTR1HCRTR2SMN1; SMN2PDE10AMAPT | |
| SCHEMBL13139073 | 0.81 | HCRTR1 (0.53) | HCRTR1HCRTR2SMN1; SMN2RECQLMAPT | |
| SCHEMBL2015167 | 0.80 | HCRTR1 (0.40) | HCRTR1HCRTR2SMN1; SMN2TSHRRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |