Sugi Predict

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SCHEMBL20152355

SCHEMBL20152355

CC(C)(C)N1CC2CC(C1)N2C(=O)c1ccc(OC(F)F)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.46
▸ RET P07949 3/20 0.44
▸ HCRTR1 O43613 1/20 0.41
▸ HCRTR2 O43614 1/20 0.41
▸ ALOX15 P16050 1/20 0.40
▸ GFER P55789 1/20 0.40
▸ ADAM17 P78536 1/20 0.40
▸ HTT P42858 2/20 0.39
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ MDM2 Q00987 1/20 0.38
▸ GAA P10253 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ ATM Q13315 1/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ HDAC3 O15379 1/20 0.35
▸ HDAC4 P56524 1/20 0.35
▸ HDAC1 Q13547 1/20 0.35
▸ HDAC7 Q8WUI4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20152354 0.90 KMT2A (0.45) ALDH1A1RETALOX15HTTMEN1
SCHEMBL22030862 0.86 ALDH1A1 (0.49) ALDH1A1RETHCRTR1HCRTR2ALOX15
SCHEMBL20071116 0.84 ALDH1A1 (0.47) ALDH1A1RETHCRTR1HCRTR2ALOX15
SCHEMBL22812035 0.82 ALDH1A1 (0.46) ALDH1A1RETHCRTR1HCRTR2ALOX15
SCHEMBL22030863 0.80 ALDH1A1 (0.46) ALDH1A1RETHCRTR1HCRTR2ALOX15
SCHEMBL22030865 0.75 KMT2A (0.49) ALDH1A1RETALOX15HTTMEN1
SCHEMBL20148732 0.74 KMT2A (0.47) ALDH1A1RETALOX15HTTMEN1
SCHEMBL20152351 0.73 RET (0.43) ALDH1A1RETHTTMEN1KMT2A
SCHEMBL20152352 0.73 CPS1 (0.48) ALDH1A1RETHTTMEN1KMT2A
SCHEMBL20152357 0.71 RET (0.46) ALDH1A1RETMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210186959-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA, INC. 2021-06-24 — — US disclosed
US-10953005-B1 Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2021-03-23 — — US disclosed
US-20190183886-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2019-06-20 — — US disclosed
US-20180134702-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134702-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF ALDH1A1 2868/4885RET 1/4885HCRTR1 2431/4885
US-10953005-B1 Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors RET, ROR1, BRAF ALDH1A1 2868/4885RET 1/4885HCRTR1 2431/4885
US-20190183886-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF ALDH1A1 2868/4885RET 1/4885HCRTR1 2431/4885
US-20210186959-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF ALDH1A1 2868/4885RET 1/4885HCRTR1 2431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.