Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1989452 | 0.90 | BCHE (0.46) | BCHEACHEPTGDR2ADORA2ATBXA2R | |
| SCHEMBL2015151 | 0.87 | SYK (0.45) | BCHEACHEPTGDR2ADORA2ATBXA2R | |
| SCHEMBL9952652 | 0.84 | BCHE (0.46) | BCHEACHEPTGDR2ADORA2ATBXA2R | |
| SCHEMBL1988633 | 0.80 | BCHE (0.44) | BCHEACHEADORA2APDE4APDE4B | |
| SCHEMBL4435275 | 0.79 | NT5E (0.44) | PTGDR2ADORA2ATBXA2RPTGDRCSNK2A2 | |
| SCHEMBL12629115 | 0.77 | ADORA2A (0.50) | BCHEACHEADORA2ASYKCLK4 | |
| SCHEMBL1989290 | 0.76 | MAPK14 (0.38) | BCHEACHESYKCYP1A2CYP3A4 | |
| SCHEMBL1990582 | 0.74 | BCHE (0.44) | BCHEACHEADORA2ASYKCLK4 | |
| SCHEMBL1991506 | 0.74 | BCHE (0.46) | BCHEACHEADORA2ACLK4CDC7 | |
| SCHEMBL1988818 | 0.74 | BCHE (0.46) | BCHEACHEADORA2ASYKPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513109-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075628-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-06-23 | — | — | WO | disclosed |