Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952652 | 0.90 | BCHE (0.46) | SYKBCHEACHETAAR1ADORA2A | |
| SCHEMBL1989290 | 0.90 | MAPK14 (0.38) | SYKBCHEACHETAAR1MAPK14 | |
| SCHEMBL2015255 | 0.87 | BCHE (0.44) | SYKBCHEACHEADORA2APTGDR2 | |
| SCHEMBL1989452 | 0.84 | BCHE (0.46) | SYKBCHEACHEADORA2APTGDR2 | |
| SCHEMBL3911088 | 0.81 | TAAR1 (0.50) | SYKBCHEACHETAAR1ADORA2A | |
| SCHEMBL19331478 | 0.80 | TAAR1 (0.47) | TAAR1ADORA2ADPP4PTGDR2TBXA2R | |
| SCHEMBL12629115 | 0.80 | ADORA2A (0.50) | SYKBCHEACHETAAR1ADORA2A | |
| SCHEMBL4434201 | 0.79 | ADORA2A (0.47) | TAAR1ADORA2ADPP4PTGDR2USP2 | |
| SCHEMBL1990582 | 0.77 | BCHE (0.44) | SYKBCHEACHEADORA2AMAPK14 | |
| SCHEMBL1988633 | 0.77 | BCHE (0.44) | BCHEACHEADORA2AMAPK14CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513109-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075628-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-06-23 | — | — | WO | disclosed |