⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154592 | 0.80 | — | — | |
| SCHEMBL18610240 | 0.76 | — | — | |
| SCHEMBL20154545 | 0.70 | LMNA (0.30) | — | |
| SCHEMBL22916172 | 0.69 | — | — | |
| SCHEMBL23641705 | 0.68 | — | — | |
| SCHEMBL20149627 | 0.65 | — | — | |
| SCHEMBL20160604 | 0.64 | — | — | |
| SCHEMBL20153256 | 0.64 | ATM (0.31) | — | |
| SCHEMBL24352143 | 0.64 | — | — | |
| SCHEMBL23555140 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133200-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |