Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.67 |
| ▸ | ITGB3 | P05106 | 18/20 | 0.67 |
| ▸ | ITGB6 | P18564 | 7/20 | 0.62 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.62 |
| ▸ | ITGB8 | P26012 | 4/20 | 0.62 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.62 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.62 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29701342 | 0.84 | ITGAV (0.70) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL20141277 | 0.84 | ITGAV (0.70) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL20139892 | 0.83 | ITGAV (0.66) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL20157714 | 0.83 | ITGAV (0.74) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL2899485 | 0.82 | ITGB3 (0.73) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL20158222 | 0.81 | ITGAV (0.67) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL20158074 | 0.81 | ITGAV (0.65) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL6421095 | 0.81 | ITGAV (1.00) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL6358670 | 0.81 | ITGAV (1.00) | ITGAVITGB3ITGB6ITGA2BITGB8 | |
| SCHEMBL6421090 | 0.81 | ITGAV (1.00) | ITGAVITGB3ITGB6ITGA2BITGB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089353-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |