Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.40 |
| ▸ | ITGAV | P06756 | 20/20 | 0.40 |
| ▸ | ITGB6 | P18564 | 4/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.35 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21282941 | 1.00 | ITGB3 (0.40) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL861269 | 0.81 | ITGB3 (0.57) | ITGB3ITGAVITGB5 | |
| SCHEMBL861506 | 0.79 | ITGB3 (0.51) | ITGB3ITGAVITGB5 | |
| SCHEMBL860614 | 0.78 | ITGB3 (0.59) | ITGB3ITGAVITGB5 | |
| SCHEMBL860336 | 0.77 | ITGB3 (0.59) | ITGB3ITGAVITGB5 | |
| SCHEMBL861676 | 0.77 | ITGB3 (0.56) | ITGB3ITGAVITGB5 | |
| SCHEMBL862008 | 0.77 | ITGB3 (0.57) | ITGB3ITGAVITGB5 | |
| SCHEMBL860404 | 0.77 | ITGB3 (0.57) | ITGB3ITGAVITGB5 | |
| SCHEMBL860620 | 0.77 | ITGB3 (0.58) | ITGB3ITGAVITGB5 | |
| SCHEMBL861296 | 0.77 | ITGB3 (0.58) | ITGB3ITGAVITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089357-A1 | INDAZOLE DERIVATIVES AS αV INTEGRIN ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |