Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23426249 | 1.00 | SMARCA2 (0.45) | SMARCA2SMARCA4PBRM1GPR119ABCB1 | |
| SCHEMBL20154090 | 0.88 | SMARCA2 (0.42) | SMARCA2SMARCA4PBRM1GPR119ABCB1 | |
| SCHEMBL30234862 | 0.88 | SMARCA2 (0.42) | SMARCA2SMARCA4PBRM1GPR119ABCB1 | |
| SCHEMBL20154073 | 0.88 | SMARCA2 (0.42) | SMARCA2SMARCA4PBRM1GPR119ABCB1 | |
| SCHEMBL20154158 | 0.82 | POLB (0.46) | SMARCA2SMARCA4PBRM1GPR119MAPT | |
| SCHEMBL23426258 | 0.81 | GPR119 (0.42) | SMARCA2SMARCA4PBRM1GPR119ABCB1 | |
| SCHEMBL30234844 | 0.80 | GPR119 (0.41) | SMARCA2SMARCA4PBRM1GPR119ABCB1 | |
| SCHEMBL20154071 | 0.80 | GPR119 (0.41) | SMARCA2SMARCA4PBRM1GPR119ABCB1 | |
| SCHEMBL25982105 | 0.79 | GPR119 (0.42) | SMARCA2SMARCA4PBRM1GPR119ABCB1 | |
| SCHEMBL4319554 | 0.79 | GPR119 (0.50) | SMARCA2SMARCA4PBRM1GPR119ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087527-A1 | PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-05-17 | — | — | WO | disclosed |