Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24014177 | 0.83 | ALDH1A1 (0.50) | ALDH1A1PKMHPGDUSP2TP53 | |
| SCHEMBL21872429 | 0.82 | ALDH1A1 (0.47) | ALDH1A1PKMHPGDUSP2TP53 | |
| SCHEMBL21872305 | 0.79 | ALDH1A1 (0.47) | ALDH1A1PKMHPGDUSP2TP53 | |
| SCHEMBL19300116 | 0.78 | HPGD (0.44) | ALDH1A1PKMHPGDUSP2TP53 | |
| SCHEMBL4509618 | 0.77 | ALDH1A1 (0.51) | ALDH1A1PKMHPGDUSP2SMN1; SMN2 | |
| SCHEMBL23431409 | 0.76 | HDAC1 (0.47) | ALDH1A1ALOX15NPC1MEN1MAPT | |
| SCHEMBL21872290 | 0.76 | ALDH1A1 (0.44) | ALDH1A1PKMHPGDUSP2TP53 | |
| SCHEMBL20229846 | 0.76 | ALDH1A1 (0.43) | ALDH1A1PKMHPGDUSP2TP53 | |
| SCHEMBL18600020 | 0.75 | ALDH1A1 (0.51) | ALDH1A1PKMHPGDSMN1; SMN2NPC1 | |
| SCHEMBL21872289 | 0.74 | ALDH1A1 (0.42) | ALDH1A1PKMHPGDUSP2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022073469-A1 | COMPOUNDS AND METHODS OF TREATING CANCERS | CULLGEN (SHANGHAI) , INC. (CN) | 2022-04-14 | — | — | WO | disclosed |
| EP-3538523-B1 | PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS | CANCER RESEARCH TECH LTD (GB) | 2021-05-19 | — | — | EP | disclosed |
| WO-2018087527-A1 | PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-05-17 | — | — | WO | disclosed |