Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154113 | 0.84 | ATR (0.49) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL20138951 | 0.81 | PIK3CD (0.45) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL20154205 | 0.66 | ATR (0.47) | PIK3CDPIK3R1PIK3CGPIK3CAMTOR | |
| SCHEMBL20143028 | 0.66 | CDC7 (0.49) | PIK3CDPIK3CATSHRNPSR1MTOR | |
| SCHEMBL13828835 | 0.65 | PIK3CA (0.67) | PIK3CDPIK3R1PIK3CGPIK3CACLK4 | |
| SCHEMBL4973147 | 0.65 | SMN1; SMN2 (0.48) | PIK3R1PIK3CACYP1A2CYP2D6NPSR1 | |
| SCHEMBL2153312 | 0.63 | PIK3CA (0.66) | PIK3CDPIK3R1PIK3CGPIK3CACLK4 | |
| SCHEMBL20154109 | 0.62 | NPSR1 (0.49) | CYP3A4TSHRNPSR1 | |
| SCHEMBL25320935 | 0.62 | PIK3CA (0.49) | PIK3CDPIK3R1PIK3CGPIK3CAUSP2 | |
| SCHEMBL31058395 | 0.62 | PIK3CA (0.49) | PIK3CDPIK3R1PIK3CGPIK3CAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538523-B1 | PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS | CANCER RESEARCH TECH LTD (GB) | 2021-05-19 | — | — | EP | disclosed |
| WO-2018087527-A1 | PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-05-17 | — | — | WO | disclosed |