Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337541 | 0.83 | SMN1; SMN2 (0.44) | SMN1; SMN2POLBALDH1A1MAPTL3MBTL1 | |
| SCHEMBL13828583 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBNPSR1ALDH1A1MAPT | |
| SCHEMBL7930954 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBALDH1A1MAPTL3MBTL1 | |
| SCHEMBL20154109 | 0.81 | NPSR1 (0.49) | SMN1; SMN2POLBNPSR1ALDH1A1MAPT | |
| SCHEMBL2148684 | 0.79 | MTOR (0.51) | SMN1; SMN2 | |
| SCHEMBL14849909 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2POLBALDH1A1MAPTL3MBTL1 | |
| SCHEMBL12068673 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2POLBALDH1A1MAPTL3MBTL1 | |
| SCHEMBL12463160 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2POLBALDH1A1MAPTL3MBTL1 | |
| SCHEMBL10706029 | 0.77 | PDE4A (0.43) | SMN1; SMN2POLBALDH1A1MAPTL3MBTL1 | |
| SCHEMBL932547 | 0.77 | ALDH1A1 (0.52) | SMN1; SMN2NPSR1ALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |