Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 19/20 | 0.53 |
| ▸ | ITGAV | P06756 | 19/20 | 0.53 |
| ▸ | ITGB6 | P18564 | 12/20 | 0.51 |
| ▸ | ITGB5 | P18084 | 12/20 | 0.51 |
| ▸ | ITGB8 | P26012 | 11/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21271427 | 0.92 | ITGB3 (0.61) | ITGB3ITGAVITGB6ITGB5ITGB8 | |
| SCHEMBL20154377 | 0.92 | ITGB3 (0.61) | ITGB3ITGAVITGB6ITGB5ITGB8 | |
| SCHEMBL29903058 | 0.92 | ITGB3 (0.61) | ITGB3ITGAVITGB6ITGB5ITGB8 | |
| SCHEMBL21271503 | 0.92 | ITGB3 (0.61) | ITGB3ITGAVITGB6ITGB5ITGB8 | |
| SCHEMBL21284325 | 0.85 | ITGB3 (0.45) | ITGB3ITGAVITGB6ITGB5ITGB8 | |
| SCHEMBL21311505 | 0.82 | ITGB3 (0.60) | ITGB3ITGAVITGB6ITGB5ITGB8 | |
| SCHEMBL21317575 | 0.81 | ITGB3 (0.53) | ITGB3ITGAVITGB6ITGB5ITGB8 | |
| SCHEMBL30487491 | 0.81 | ITGB3 (0.53) | ITGB3ITGAVITGB6ITGB5ITGB8 | |
| SCHEMBL21271484 | 0.80 | ITGB3 (0.61) | ITGB3ITGAVITGB6ITGB5ITGB8 | |
| SCHEMBL21271488 | 0.80 | ITGB3 (0.61) | ITGB3ITGAVITGB6ITGB5ITGB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538528-B1 | PYRROLE AMIDES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2018089360-A1 | PYRROLE AMIDES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |