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SCHEMBL20154878

SCHEMBL20154878

CC(C)C(=O)Nc1nc2c(ncn2[C@H]2C[C@H](F)[C@@H](CO)O2)c(=O)[nH]1

nearest known ligand 0.82

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.71
▸ POLA1 P09884 1/20 0.53
▸ TAS1R3 Q7RTX0 1/20 0.46
▸ TAS1R1 Q7RTX1 1/20 0.46
▸ HPGD P15428 1/20 0.41
▸ HIF1A Q16665 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ PNP P00491 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ TP53 P04637 1/20 0.39
▸ HTT P42858 1/20 0.39
▸ PDE4D Q08499 1/20 0.39
▸ PDE3A Q14432 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ RXFP1 Q9HBX9 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18521398 1.00 KDM4E (0.71) KDM4EPOLA1TAS1R3TAS1R1HPGD
SCHEMBL26197044 1.00 KDM4E (0.71) KDM4EPOLA1TAS1R3TAS1R1HPGD
SCHEMBL25507075 0.90 KDM4E (0.72) KDM4EPOLA1TAS1R3TAS1R1HIF1A
SCHEMBL25504733 0.90 KDM4E (0.72) KDM4EPOLA1TAS1R3TAS1R1HPGD
SCHEMBL10068104 0.90 KDM4E (0.72) KDM4EPOLA1TAS1R3TAS1R1HIF1A
SCHEMBL264545 0.90 KDM4E (0.72) KDM4EPOLA1TAS1R3TAS1R1HIF1A
SCHEMBL25797554 0.90 KDM4E (0.72) KDM4EPOLA1TAS1R3TAS1R1HPGD
SCHEMBL12714741 0.90 KDM4E (0.72) KDM4EPOLA1TAS1R3TAS1R1HIF1A
SCHEMBL20346237 0.90 KDM4E (0.72) KDM4EPOLA1TAS1R3TAS1R1HIF1A
SCHEMBL264546 0.90 KDM4E (0.72) KDM4EPOLA1TAS1R3TAS1R1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11685761-B2 Cyclic di-nucleotide compounds as sting agonists MERCK SHARP & DOHME LLC (US) 2023-06-27 — — US disclosed
EP-3922637-A1 MODIFIED OLIGONUCLEOTIDES FOR USE IN TREATMENT OF TAUOPATHIES Janssen Pharmaceutica NV (BE) 2021-12-15 — — EP disclosed
US-10793859-B2 Modified oligonucleotides and methods of use Janssen Biopharma, Inc. (US) 2020-10-06 — — US disclosed
WO-2019175260-A2 MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE IN TAUOPATHIES JANSSEN PHARMACEUTICA NV (BE) 2019-09-19 — — WO disclosed
US-20180135054-A1 MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE ALIOS BIOPHARMA, INC. (US) 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10793859-B2 Modified oligonucleotides and methods of use NSUN2, ADAR, POLM KDM4E 2928/4885POLA1 311/4885TAS1R3 4579/4885
US-20180135054-A1 MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE NSUN2, ADAR, POLM KDM4E 2928/4885POLA1 311/4885TAS1R3 4579/4885
US-11685761-B2 Cyclic di-nucleotide compounds as sting agonists STING1, CGAS, IFNAR1 KDM4E 4005/4885POLA1 103/4885TAS1R3 534/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.