SCHEMBL20154888

SCHEMBL20154888

BC1(B)Cc2ccc(Cc3cc(C4CC(O)CC(CO)O4)c(F)cc3Cl)cc21

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 20/20 0.49
SLC5A1 P13866 13/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20154938 0.90 SLC5A2 (0.49) SLC5A2SLC5A1
SCHEMBL20155267 0.89 SLC5A2 (0.41) SLC5A2SLC5A1
SCHEMBL20155211 0.87 SLC5A2 (0.63) SLC5A2SLC5A1
SCHEMBL20155579 0.84 SLC5A2 (0.46) SLC5A2SLC5A1
SCHEMBL20154885 0.81 SLC5A1 (0.48) SLC5A2SLC5A1
SCHEMBL20154944 0.81 SLC5A2 (0.52) SLC5A2SLC5A1
SCHEMBL20154941 0.79 SLC5A2 (0.51) SLC5A2SLC5A1
SCHEMBL22590676 0.79 SLC5A2 (0.75) SLC5A2SLC5A1
SCHEMBL20154946 0.78 SLC5A2 (0.48) SLC5A2SLC5A1
SCHEMBL20155259 0.76 SLC5A2 (0.47) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018089449-A1 BENZOCYCLOBUTANE DERIVATIVES USEFUL AS DUAL SGLT1/SGLT2 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2018-05-17 WO disclosed