Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.44 |
| ▸ | FEN1 | P39748 | 3/20 | 0.44 |
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | LATS1 | O95835 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20155234 | 0.78 | IRAK1 (0.51) | STK17BSTK17ALATS1IRAK1IRAK4 | |
| SCHEMBL20154907 | 0.76 | STK17B (0.49) | STK17BSTK17ALATS1MALT1BCHE | |
| SCHEMBL19490770 | 0.73 | MALT1 (0.48) | ALOX5APFEN1STK17BSTK17ALATS1 | |
| SCHEMBL3336071 | 0.70 | HRH4 (0.60) | ALOX5APLATS1BCHE | |
| SCHEMBL20154893 | 0.69 | IRAK4 (0.55) | IRAK1IRAK4 | |
| SCHEMBL4099481 | 0.69 | ACP1 (0.53) | FGFR1IRAK4 | |
| SCHEMBL4269455 | 0.69 | LATS1 (0.50) | STK17BSTK17ALATS1MALT1BCHE | |
| SCHEMBL4112500 | 0.69 | ACP1 (0.50) | FGFR1IRAK1IRAK4 | |
| SCHEMBL4113143 | 0.69 | IRAK4 (0.44) | IRAK1IRAK4 | |
| SCHEMBL19591348 | 0.68 | MALT1 (0.49) | MALT1BCHEBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10822327-B2 | 2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof | ZHEJIANG UNIVERSITY (CN) | 2020-11-03 | — | — | US | disclosed |
| WO-2018086547-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | 浙江大学 | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10822327-B2 | 2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof | CHEK1, CHEK2, PLK1 | ALOX5AP 4468/4885FEN1 405/4885STK17B 206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.