Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.60 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
| ▸ | LATS1 | O95835 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778944 | 0.92 | HRH3 (0.59) | HRH4NUDT1HRH3TLR8 | |
| SCHEMBL3909008 | 0.84 | STK17B (0.55) | BCHEALOX5APLATS1 | |
| SCHEMBL12355030 | 0.81 | ROCK1 (0.53) | HRH4NUDT1 | |
| SCHEMBL15757277 | 0.81 | CYP2D6 (0.56) | HRH4BCHELATS1 | |
| SCHEMBL14907944 | 0.79 | BCHE (0.49) | HRH4HRH3BCHEALOX5APLATS1 | |
| SCHEMBL3339614 | 0.79 | HRH3 (0.61) | HRH4NUDT1HRH3TLR8 | |
| SCHEMBL6174559 | 0.78 | BCHE (0.54) | BCHELATS1 | |
| SCHEMBL20974133 | 0.78 | SUV39H2 (0.46) | BCHEALOX5APLATS1 | |
| SCHEMBL17784777 | 0.78 | STK17B (0.48) | HRH4BCHEALOX5APLATS1 | |
| SCHEMBL23640753 | 0.77 | KDM4D (0.58) | BCHEALOX5APLATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796297-B2 | 4-substituted-2-amino-pyrimidine derivatives | ABBVIE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8268846-B2 | Amino heterocyclic linked pyrimidine derivatives | ABBOTT LABORATORIES (US) | 2012-09-18 | — | — | US | disclosed |
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100016344-A1 | AMINO HETEROCYCLIC LINKED PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016344-A1 | AMINO HETEROCYCLIC LINKED PYRIMIDINE DERIVATIVES | DPYD, TYMS, UMPS | HRH4 2024/4885NUDT1 6/4885HRH3 2456/4885 |
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | HRH2, HRH4, HRH3 | HRH4 2/4885NUDT1 249/4885HRH3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.