Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 14/20 | 0.63 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.49 |
| ▸ | AXL | P30530 | 3/20 | 0.49 |
| ▸ | MERTK | Q12866 | 2/20 | 0.49 |
| ▸ | SELP | P16109 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154924 | 0.81 | CHEK1 (0.44) | CHEK1TYRO3MERTKIRAK4 | |
| SCHEMBL20154981 | 0.81 | CHEK1 (0.74) | CHEK1 | |
| SCHEMBL21299939 | 0.80 | CHEK1 (0.73) | CHEK1 | |
| SCHEMBL28887993 | 0.72 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL28823771 | 0.72 | CHEK1 (0.60) | CHEK1IRAK4 | |
| Hydrochloric Acid SCHEMBL23302465 | 0.71 | CHEK1 (0.58) | CHEK1IRAK4 | |
| SCHEMBL20154919 | 0.71 | CHEK1 (0.65) | CHEK1TYRO3AXLMERTK | |
| SCHEMBL20154918 | 0.71 | CHEK1 (0.65) | CHEK1TYRO3AXLMERTK | |
| SCHEMBL20155640 | 0.71 | CHEK1 (0.65) | CHEK1TYRO3AXLMERTK | |
| SCHEMBL20154917 | 0.71 | CHEK1 (0.63) | CHEK1MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3530656-B1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | UNIV ZHEJIANG (CN) | 2022-01-05 | — | — | EP | disclosed |
| US-10822327-B2 | 2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof | ZHEJIANG UNIVERSITY (CN) | 2020-11-03 | — | — | US | disclosed |
| EP-3530656-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | Zhejiang University (CN) | 2019-08-28 | — | — | EP | disclosed |
| WO-2018086547-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | 浙江大学 | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10822327-B2 | 2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof | CHEK1, CHEK2, PLK1 | CHEK1 1/4885TYRO3 719/4885AXL 466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.