SCHEMBL20155174

SCHEMBL20155174

CN(C)c1ccc(C2CC(O)CC(CO)O2)cc1Cc1ccc2c(c1)CC2

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 20/20 0.48
SLC5A1 P13866 17/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20154887 0.82 SLC5A2 (0.52) SLC5A2SLC5A1
SCHEMBL20140093 0.78 SLC5A2 (0.76) SLC5A2SLC5A1
SCHEMBL20155582 0.76 SLC5A2 (0.49) SLC5A2SLC5A1
SCHEMBL20155222 0.75 SLC5A1 (0.64) SLC5A2SLC5A1
SCHEMBL20154931 0.74 SLC5A2 (0.64) SLC5A2SLC5A1
SCHEMBL20154934 0.74 SLC5A2 (0.48) SLC5A2SLC5A1
SCHEMBL12167131 0.74 SLC5A2 (0.61) SLC5A2SLC5A1
SCHEMBL19189221 0.74 SLC5A2 (0.50) SLC5A2SLC5A1
SCHEMBL20155213 0.73 SLC5A2 (0.53) SLC5A2SLC5A1
SCHEMBL20155238 0.73 SLC5A2 (0.48) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018089449-A1 BENZOCYCLOBUTANE DERIVATIVES USEFUL AS DUAL SGLT1/SGLT2 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2018-05-17 WO disclosed