Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 13/20 | 0.60 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17764693 | 0.89 | IRAK1 (0.60) | IRAK1BCDIN3DGPR119SYKJAK2 | |
| SCHEMBL20155228 | 0.87 | KDM4E (0.53) | IRAK1BCDIN3DGPR119SYKUSP30 | |
| SCHEMBL20154900 | 0.86 | IRAK1 (0.53) | IRAK1GPR119IRAK4USP30 | |
| SCHEMBL22617552 | 0.85 | TLR8 (0.51) | IRAK1GPR119IRAK4 | |
| SCHEMBL17764613 | 0.84 | IRAK1 (0.83) | IRAK1IRAK4 | |
| SCHEMBL22617556 | 0.83 | IRAK1 (0.51) | IRAK1BCDIN3DGPR119SYK | |
| SCHEMBL20154979 | 0.82 | BCDIN3D (0.53) | BCDIN3DGPR119SYK | |
| SCHEMBL21299900 | 0.80 | IRAK1 (0.55) | IRAK1GPR119JAK3IRAK4USP30 | |
| SCHEMBL22617551 | 0.80 | IRAK1 (0.55) | IRAK1GPR119JAK3IRAK4USP30 | |
| SCHEMBL17764717 | 0.79 | IRAK1 (0.74) | IRAK1IRAK4USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10822327-B2 | 2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof | ZHEJIANG UNIVERSITY (CN) | 2020-11-03 | — | — | US | disclosed |
| WO-2018086547-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | 浙江大学 | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10822327-B2 | 2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof | CHEK1, CHEK2, PLK1 | IRAK1 679/4885BCDIN3D 2772/4885GPR119 3463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.