Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24886301 | 0.84 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2CYP2D6GLO1EGLN1 | |
| SCHEMBL20156006 | 0.84 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2CYP2D6GLO1EGLN1 | |
| SCHEMBL23912850 | 0.81 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2CYP2D6GLO1MAPT | |
| SCHEMBL14838887 | 0.79 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2CYP2D6GLO1EGLN1 | |
| SCHEMBL23953799 | 0.74 | NPSR1 (0.43) | ALDH1A1SMN1; SMN2CYP2D6GLO1EGLN1 | |
| SCHEMBL20156005 | 0.73 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2CYP2D6GLO1 | |
| SCHEMBL14346035 | 0.72 | NPSR1 (0.42) | ALDH1A1SMN1; SMN2CYP2D6GLO1EGLN1 | |
| SCHEMBL27379728 | 0.71 | MAPT (0.37) | ALDH1A1SMN1; SMN2CYP2D6MAPTNPSR1 | |
| SCHEMBL16410842 | 0.71 | NPSR1 (0.41) | ALDH1A1SMN1; SMN2CYP2D6GLO1EGLN1 | |
| SCHEMBL15166437 | 0.71 | NPSR1 (0.41) | ALDH1A1SMN1; SMN2CYP2D6GLO1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089358-A1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |