Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.33 |
| ▸ | GAA | P10253 | 8/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.33 |
| ▸ | HPGD | P15428 | 8/20 | 0.33 |
| ▸ | CASP1 | P29466 | 7/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | GLA | P06280 | 5/20 | 0.33 |
| ▸ | CASP7 | P55210 | 5/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 6/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 3/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | PDE8B | O95263 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23171974 | 1.00 | KDM4E (0.33) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL20091846 | 0.73 | YTHDC1 (0.35) | TSHR | |
| SCHEMBL20092555 | 0.71 | ATR (0.38) | ATR | |
| SCHEMBL20091689 | 0.70 | YTHDC1 (0.40) | GAAHPGDTSHRATRKMT2A | |
| SCHEMBL20156103 | 0.69 | TYK2 (0.30) | — | |
| SCHEMBL23171970 | 0.68 | TYK2 (0.32) | ATR | |
| SCHEMBL20156146 | 0.68 | TYK2 (0.30) | — | |
| SCHEMBL20156031 | 0.68 | PARP1 (0.31) | HPGDTSHR | |
| SCHEMBL20092927 | 0.68 | YTHDC1 (0.37) | HPGDTSHRATRRET | |
| SCHEMBL20093112 | 0.67 | ROS1 (0.36) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647713-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | KDM4E 391/4885ALDH1A1 4827/4885GAA 1899/4885 |
| US-10647713-B2 | TYK2 inhibitors and uses thereof | TYK2, JAK2, JAK1 | KDM4E 391/4885ALDH1A1 4827/4885GAA 1899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.