SCHEMBL20156178

SCHEMBL20156178

N#Cc1cc(-n2c3ccccc3c3cc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)ccc32)ccc1-c1nc(-c2ccccc2)nc(-c2ccccc2)n1

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
AR P10275 7/20 0.36
XDH P47989 1/20 0.35
ALOX5AP P20292 2/20 0.35
FEN1 P39748 2/20 0.35
ABCG2 Q9UNQ0 1/20 0.34
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33
MAPK1 P28482 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
SCN9A Q15858 2/20 0.33
CYP2C9 P11712 1/20 0.33
S1PR1 P21453 1/20 0.33
S1PR3 Q99500 1/20 0.33
NR3C1 P04150 1/20 0.32
PGR P06401 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20156207 0.97 AR (0.38) ARXDHALOX5APFEN1ABCG2
SCHEMBL20114890 0.95 AR (0.36) ARXDHALOX5APFEN1ABCG2
SCHEMBL20156135 0.94 AR (0.38) ARXDHABCG2ALDH1A1LMNA
SCHEMBL20156204 0.91 AR (0.39) ARXDHALOX5APFEN1ABCG2
SCHEMBL19943088 0.90 AR (0.36) ARXDHALOX5APFEN1ABCG2
SCHEMBL20114699 0.89 LMNA (0.39) ARXDHALOX5APFEN1ABCG2
SCHEMBL20114888 0.89 AR (0.38) ARXDHALOX5APFEN1ABCG2
SCHEMBL20114994 0.89 AR (0.39) ARXDHALOX5APFEN1ABCG2
SCHEMBL21108050 0.89 AR (0.36) ARXDHALOX5APFEN1ABCG2
SCHEMBL20849560 0.88 AR (0.35) ARXDHABCG2SCN9ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10421746-B2 Organic molecules, especially for use in organic optoelectronic devices CYNORA GMBH (DE) 2019-09-24 US disclosed
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180134686-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN ORGANIC OPTOELECTRONIC DEVICES OR10J3, EPCAM, F12 AR 3892/4885XDH 122/4885ALOX5AP 4191/4885
US-10421746-B2 Organic molecules, especially for use in organic optoelectronic devices OR10J3, EPCAM, F12 AR 3892/4885XDH 122/4885ALOX5AP 4191/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.