Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 14/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23912916 | 0.85 | MAPT (0.40) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL20156007 | 0.83 | CYP1A2 (0.40) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL20156362 | 0.80 | CYP1A2 (0.39) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL20156289 | 0.78 | SUCNR1 (0.41) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL20156079 | 0.76 | SUCNR1 (0.38) | SUCNR1MEN1KMT2AKDM4E | |
| SCHEMBL20156254 | 0.74 | SUCNR1 (0.39) | SUCNR1MEN1KMT2AKDM4E | |
| SCHEMBL20156307 | 0.73 | SUCNR1 (0.40) | SUCNR1MEN1KMT2AKDM4E | |
| SCHEMBL20156365 | 0.73 | MAPT (0.39) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL20156244 | 0.72 | CYP2D6 (0.44) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL20156039 | 0.72 | SUCNR1 (0.38) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538527-B1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2018089358-A1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |