Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUCNR1 | Q9BXA5 | 18/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | OXGR1 | Q96P68 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156367 | 0.94 | SUCNR1 (0.41) | SUCNR1OXGR1BDKRB1 | |
| SCHEMBL23912916 | 0.90 | MAPT (0.40) | SUCNR1KDM4EMEN1KMT2AOXGR1 | |
| SCHEMBL20156361 | 0.85 | NQO2 (0.30) | ALDH1A1 | |
| SCHEMBL20156362 | 0.84 | CYP1A2 (0.39) | SUCNR1MEN1KMT2AOXGR1BDKRB1 | |
| SCHEMBL20156279 | 0.79 | SUCNR1 (0.37) | SUCNR1OXGR1 | |
| SCHEMBL20156365 | 0.77 | MAPT (0.39) | KDM4EMEN1LMNAKMT2AALDH1A1 | |
| SCHEMBL20156243 | 0.76 | MAPT (0.41) | SUCNR1KDM4EMEN1KMT2A | |
| SCHEMBL23912908 | 0.75 | NPC1 (0.34) | SUCNR1KDM4EMEN1KMT2AOXGR1 | |
| SCHEMBL20156364 | 0.75 | SUCNR1 (0.39) | SUCNR1OXGR1BDKRB1 | |
| SCHEMBL20156254 | 0.73 | SUCNR1 (0.39) | SUCNR1KDM4EMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538527-B1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2018089358-A1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |
| US-9248131-B2 | Aquaporin modulators and methods of using them for the treatment of edema and fluid imbalance | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2016-02-02 | — | — | US | disclosed |