Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12380192 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL7528107 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL28746286 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL3835193 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL9160736 | 0.73 | MEN1 (0.48) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL3626130 | 0.71 | — | — | |
| SCHEMBL13440656 | 0.70 | BRD4 (0.55) | SMN1; SMN2MEN1KMT2AKDM4EGAA | |
| SCHEMBL7272830 | 0.70 | GAA (0.52) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL6731657 | 0.70 | — | — | |
| SCHEMBL4761737 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018185236-A1 | PZRAYOLE DERIVATIVES USED AS INVERSE AGONISTS OF THE ROR GAMMA (T) RETINOID-RELATED ORPHAN GAMMA RECEPTOR | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-10-11 | — | — | WO | disclosed |
| WO-2018089904-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS | 3-V BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |