Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | SOAT2 | O75908 | 2/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | DNM2 | P50570 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835193 | 0.80 | SMN1; SMN2 (0.46) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4142888 | 0.78 | MEN1 (0.61) | MEN1KMT2ASMN1; SMN2ALDH1A1ASAH1 | |
| SCHEMBL7532787 | 0.75 | SMN1; SMN2 (0.41) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL25059568 | 0.73 | CYP1A2 (0.39) | MEN1KMT2ACYP1A2TLR8CRHR1 | |
| SCHEMBL20156432 | 0.73 | SMN1; SMN2 (0.46) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL28746286 | 0.73 | SMN1; SMN2 (0.46) | MEN1KMT2ASMN1; SMN2HTTLMNA | |
| SCHEMBL7528107 | 0.73 | SMN1; SMN2 (0.46) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL4132285 | 0.72 | MEN1 (0.58) | MEN1KMT2ASMN1; SMN2ALDH1A1ASAH1 | |
| SCHEMBL4135897 | 0.72 | MEN1 (0.58) | MEN1KMT2ASMN1; SMN2ALDH1A1ASAH1 | |
| SCHEMBL4136924 | 0.72 | MEN1 (0.58) | MEN1KMT2ASMN1; SMN2ALDH1A1ASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389660-A | Hypotensive agents | MERCK & CO., INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5164407-A | Hypotensive agents | MERCK & CO., INC. (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0407102-A1 | Substituted imidazo-fused 5-membered ring heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1991-01-09 | — | — | EP | disclosed |