Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 10/20 | 0.74 |
| ▸ | ARG2 | P78540 | 10/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19576669 | 0.96 | ARG1 (0.80) | ARG1ARG2SIGMAR1SMN1; SMN2MEN1 | |
| SCHEMBL20683474 | 0.92 | ARG1 (0.63) | ARG1ARG2SIGMAR1SMN1; SMN2POLB | |
| SCHEMBL20683523 | 0.91 | ARG1 (0.73) | ARG1ARG2SIGMAR1SMN1; SMN2MEN1 | |
| SCHEMBL895581 | 0.90 | ARG1 (0.93) | ARG1ARG2SIGMAR1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL894579 | 0.89 | ARG1 (0.91) | ARG1ARG2SIGMAR1MEN1KMT2A | |
| SCHEMBL20683399 | 0.87 | ARG1 (0.67) | ARG1ARG2SIGMAR1HRH3 | |
| SCHEMBL12292593 | 0.87 | ARG1 (0.66) | ARG1ARG2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL19575883 | 0.85 | ARG1 (1.00) | ARG1ARG2SIGMAR1MEN1KMT2A | |
| SCHEMBL895916 | 0.85 | ARG1 (1.00) | ARG1ARG2SIGMAR1MEN1KMT2A | |
| SCHEMBL30772139 | 0.85 | ARG1 (1.00) | ARG1ARG2SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |
| WO-2018089490-A1 | ARGINASE INHIBITOR COMBINATION THERAPIES | CALITHERA BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |