Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 14/20 | 0.36 |
| ▸ | ARG2 | P78540 | 14/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL895350 | 0.89 | ARG1 (0.49) | ARG1ARG2 | |
| SCHEMBL895346 | 0.89 | ARG1 (0.49) | ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL895509 | 0.89 | ARG1 (0.48) | ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL895507 | 0.89 | ARG1 (0.48) | ARG1ARG2 | |
| SCHEMBL20683536 | 0.77 | ARG1 (0.51) | ARG1ARG2GRM2GRM3CYP2C9 | |
| SCHEMBL18323843 | 0.75 | ARG1 (0.52) | ARG1ARG2 | |
| SCHEMBL18323853 | 0.75 | ARG1 (0.47) | ARG1ARG2GRM2GRM3 | |
| SCHEMBL18323849 | 0.75 | HTR2C (0.43) | ARG1ARG2 | |
| SCHEMBL18323842 | 0.74 | ARG1 (0.48) | ARG1ARG2GRM2GRM3 | |
| SCHEMBL18323835 | 0.74 | KDM1A (0.45) | ARG1ARG2ADRA1AOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |
| WO-2018089490-A1 | ARGINASE INHIBITOR COMBINATION THERAPIES | CALITHERA BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |