Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 5/20 | 0.66 |
| ▸ | ARG2 | P78540 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28256958 | 0.93 | ARG1 (0.60) | ARG1ARG2KDM4EALDH1A1MAPK1 | |
| SCHEMBL895828 | 0.85 | ARG1 (0.90) | ARG1ARG2MAPK1CYP1A2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL894293 | 0.84 | ARG1 (0.88) | ARG1ARG2MAPK1CYP1A2SMN1; SMN2 | |
| SCHEMBL895842 | 0.83 | ARG1 (0.88) | ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL895757 | 0.82 | ARG1 (0.85) | ARG1ARG2 | |
| SCHEMBL10265627 | 0.82 | ARG1 (0.72) | ARG1ARG2KDM4EALDH1A1MAPK1 | |
| SCHEMBL894844 | 0.80 | ARG1 (1.00) | ARG1ARG2 | |
| SCHEMBL16309676 | 0.80 | ARG1 (0.85) | ARG1ARG2 | |
| SCHEMBL20156734 | 0.79 | ARG1 (0.62) | ARG1ARG2KDM4EALDH1A1MAPK1 | |
| SCHEMBL28817969 | 0.79 | ARG1 (0.44) | ARG1ARG2ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089490-A1 | ARGINASE INHIBITOR COMBINATION THERAPIES | CALITHERA BIOSCIENCES, INC. (US) | 2018-05-17 | — | — | WO | disclosed |