SCHEMBL20156757

SCHEMBL20156757

C[Si](c1ccccc1)(c1ccccc1)c1ccc(-c2ccc([Si](c3ccccc3)(c3ccccc3)c3ccccc3)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.41
ESR2 Q92731 1/20 0.41
NR1H2 P55055 2/20 0.37
NR1H3 Q13133 2/20 0.37
ALDH1A1 P00352 3/20 0.36
TAAR1 Q96RJ0 2/20 0.34
KIF11 P52732 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.33
RAB9A P51151 3/20 0.33
NPC1 O15118 2/20 0.33
HPGD P15428 2/20 0.33
HSD17B10 Q99714 2/20 0.33
CYP1A2 P05177 2/20 0.33
PTGS2 P35354 1/20 0.33
MAPK1 P28482 1/20 0.33
POLB P06746 1/20 0.33
NFKB1 P19838 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23532322 0.87 ALDH1A1 (0.50) ESR1ESR2ALDH1A1TAAR1KIF11
SCHEMBL3292244 0.87 ALDH1A1 (0.47) ESR1ESR2ALDH1A1TAAR1KIF11
SCHEMBL15975759 0.87 ALDH1A1 (0.47) ESR1ESR2ALDH1A1TAAR1KIF11
SCHEMBL2005519 0.87 ALDH1A1 (0.47) ESR1ESR2ALDH1A1TAAR1KIF11
SCHEMBL15975760 0.86 ESR1 (0.41) ESR1ESR2NR1H2NR1H3ALDH1A1
SCHEMBL22198379 0.86 ESR1 (0.58) ESR1ESR2NR1H2NR1H3ALDH1A1
SCHEMBL9319701 0.85 ALDH1A1 (0.53) ESR2ALDH1A1TAAR1KIF11SMN1; SMN2
SCHEMBL3889979 0.85 ALDH1A1 (0.53) ESR2ALDH1A1TAAR1KIF11SMN1; SMN2
SCHEMBL28720090 0.85 ALDH1A1 (0.53) ESR2ALDH1A1TAAR1KIF11SMN1; SMN2
SCHEMBL18682233 0.85 ALDH1A1 (0.53) ESR2ALDH1A1TAAR1KIF11SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220153759-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2022-05-19 US disclosed
US-11031560-B2 Compound and organic electronic element comprising same LG CHEM, LTD. (KR) 2021-06-08 US disclosed
US-20180138422-A1 COMPOUND AND ORGANIC ELECTRONIC ELEMENT COMPRISING SAME LG CHEM, LTD. (KR) 2018-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11031560-B2 Compound and organic electronic element comprising same OR10J3, ESR1, ETV6 ESR1 2/4885ESR2 13/4885NR1H2 1270/4885
US-20220153759-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OCIAD1, ICOSLG ESR1 233/4885ESR2 326/4885NR1H2 1052/4885
US-20180138422-A1 COMPOUND AND ORGANIC ELECTRONIC ELEMENT COMPRISING SAME OR10J3, ESR1, ETV6 ESR1 2/4885ESR2 13/4885NR1H2 1270/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.