Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.51 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.51 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156830 | 0.95 | MTOR (0.51) | MTORRPTORMLST8MAPK14TACR3 | |
| SCHEMBL20156947 | 0.88 | MTOR (0.45) | MTORRPTORMLST8 | |
| SCHEMBL20140200 | 0.87 | MTOR (0.59) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20156943 | 0.87 | GAA (0.49) | MTORRPTORMLST8MAPK14MAPT | |
| SCHEMBL20156813 | 0.86 | MTOR (0.47) | MTORRPTORMLST8MAPK14KDM4E | |
| SCHEMBL20140235 | 0.86 | MTOR (0.67) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20140824 | 0.86 | MTOR (0.67) | MTORRPTORMLST8KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL20141710 | 0.84 | MTOR (0.43) | MTORRPTORMLST8 | |
| SCHEMBL20156918 | 0.84 | MTOR (0.55) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20139962 | 0.84 | MTOR (0.55) | MTORRPTORMLST8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |