Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.42 |
| ▸ | GHSR | Q92847 | 5/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156829 | 0.96 | MTOR (0.43) | MTORRPTORMLST8CHRM4GHSR | |
| Trifluoroacetic Acid SCHEMBL20141710 | 0.95 | MTOR (0.43) | MTORRPTORMLST8CHRM4GHSR | |
| Trifluoroacetic Acid SCHEMBL20140975 | 0.91 | CHRM4 (0.42) | MTORRPTORMLST8CHRM4CHRM2 | |
| Trifluoroacetic Acid SCHEMBL20140974 | 0.91 | CHRM4 (0.42) | MTORRPTORMLST8CHRM4CHRM2 | |
| SCHEMBL20156948 | 0.88 | MTOR (0.51) | MTORRPTORMLST8 | |
| SCHEMBL20141016 | 0.88 | MTOR (0.53) | MTORRPTORMLST8CHRM4GRM1 | |
| SCHEMBL20142004 | 0.87 | MTOR (0.47) | MTORRPTORMLST8CHRM4GRM1 | |
| SCHEMBL20142001 | 0.87 | MTOR (0.47) | MTORRPTORMLST8CHRM4GRM1 | |
| SCHEMBL20141589 | 0.84 | MTOR (0.43) | MTORRPTORMLST8CHRM4GRM1 | |
| SCHEMBL20141592 | 0.84 | MTOR (0.43) | MTORRPTORMLST8CHRM4GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |