Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14456485 | 0.74 | HDAC8 (0.45) | HRH3HDAC8HDAC6ACHEAOC3 | |
| SCHEMBL24831135 | 0.70 | HRH3 (0.56) | HRH3HDAC8HDAC6ACHEHTR1A | |
| SCHEMBL17481523 | 0.70 | HRH3 (0.50) | HRH3HDAC8HDAC6ACHEBCHE | |
| SCHEMBL20157104 | 0.69 | HRH3 (0.47) | HRH3BCHEHTR1AHTR2CHTR2B | |
| SCHEMBL17481522 | 0.66 | ESR1 (0.59) | HRH3HDAC8HDAC6ACHEBCHE | |
| SCHEMBL8251560 | 0.66 | HRH3 (0.50) | HRH3HDAC8HDAC6KDM4EMEN1 | |
| SCHEMBL23222675 | 0.66 | — | — | |
| SCHEMBL14924466 | 0.64 | HTR7 (0.52) | HRH3ACHEBCHEHTR1AHTR2C | |
| SCHEMBL7768079 | 0.63 | HRH3 (0.84) | HRH3HDAC8HDAC6 | |
| SCHEMBL27707407 | 0.63 | SKP2 (0.55) | HRH3HDAC8HDAC6ACHEHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |