SCHEMBL20157598

SCHEMBL20157598

COc1ccc(B2OC(C)(C)C(C)(C)O2)c(C(=O)c2ccc(C)cc2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.52
HTT P42858 2/20 0.52
NPSR1 Q6W5P4 1/20 0.52
ALDH1A1 P00352 4/20 0.48
POLB P06746 1/20 0.47
NPC1 O15118 3/20 0.45
UCHL1 P09936 1/20 0.43
CYP2C9 P11712 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
MEN1 O00255 2/20 0.41
RAB9A P51151 2/20 0.41
KMT2A Q03164 2/20 0.41
HPGD P15428 2/20 0.41
LMNA P02545 4/20 0.40
CYP1A2 P05177 2/20 0.40
CYP2C19 P33261 2/20 0.40
PGR P06401 1/20 0.40
CYP2D6 P10635 1/20 0.40
SLC6A2 P23975 1/20 0.40
PDE4A P27815 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20157806 0.90 HTT (0.49) MAPTHTTNPSR1ALDH1A1POLB
SCHEMBL29582110 0.89 POLB (0.59) MAPTHTTNPSR1ALDH1A1POLB
SCHEMBL18125724 0.89 POLB (0.59) MAPTHTTNPSR1ALDH1A1POLB
SCHEMBL20157840 0.89 HTT (0.48) MAPTHTTNPSR1ALDH1A1POLB
SCHEMBL21362390 0.87 UCHL1 (0.50) MAPTHTTNPSR1ALDH1A1POLB
SCHEMBL29272831 0.81 SMN1; SMN2 (0.48) MAPTALDH1A1POLBNPC1UCHL1
SCHEMBL29853895 0.80 KDM4E (0.49) MAPTHTTNPSR1ALDH1A1POLB
SCHEMBL19946115 0.80 KDM4E (0.49) MAPTHTTNPSR1ALDH1A1POLB
SCHEMBL20157375 0.79 NPC1 (0.47) MAPTHTTNPSR1ALDH1A1POLB
SCHEMBL20157423 0.75 SRD5A2 (0.36) MAPTHTTALDH1A1UCHL1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018086605-A1 NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF 山东罗欣药业集团股份有限公司 2018-05-17 WO disclosed