Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29454533 | 0.84 | TLR7 (0.49) | NUDT1TLR7MAPT | |
| SCHEMBL20157656 | 0.73 | TYRO3 (0.49) | DYRK1APDE3BPDE3AP2RY12 | |
| SCHEMBL7878924 | 0.69 | MAPT (0.44) | ACHEGDAMAPTPDE3BPDE3A | |
| SCHEMBL16300227 | 0.68 | TLR7 (0.51) | TLR7 | |
| SCHEMBL25659408 | 0.68 | TSHR (0.41) | NUDT1TLR7TSHR | |
| SCHEMBL13354614 | 0.64 | GDA (0.47) | BRD4ACHEGDAMAPTDYRK1A | |
| SCHEMBL21364208 | 0.64 | TLR7 (0.40) | NUDT1TLR7TSHR | |
| SCHEMBL24066751 | 0.62 | MAPT (0.46) | NUDT1TLR7BRD4MAPTPDE3B | |
| SCHEMBL10002246 | 0.62 | TSHR (0.37) | NUDT1TLR7TSHR | |
| SCHEMBL20157464 | 0.61 | TSHR (0.36) | NUDT1TLR7TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539963-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND USE | Livo (Shanghai) Pharmaceutical Co., Ltd (CN) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018086593-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND USE | 礼沃（上海）医药科技有限公司 | 2018-05-17 | — | — | WO | disclosed |