Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 2/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 18/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 18/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 9/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29475651 | 0.85 | TYRO3 (0.49) | TYRO3DYRK1BPDE3BPDE3AP2RY12 | |
| SCHEMBL30323763 | 0.83 | TYRO3 (0.53) | TYRO3DYRK1BPDE3BPDE3AP2RY12 | |
| SCHEMBL20157605 | 0.73 | NUDT1 (0.39) | PDE3BPDE3AP2RY12DYRK1A | |
| SCHEMBL20157445 | 0.72 | PDE3B (0.45) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL28671355 | 0.72 | TYRO3 (0.56) | TYRO3DYRK1BPDE3BPDE3AP2RY12 | |
| SCHEMBL29454533 | 0.72 | TLR7 (0.49) | — | |
| SCHEMBL20157464 | 0.71 | TSHR (0.36) | FGFR1 | |
| SCHEMBL11904050 | 0.70 | TYRO3 (0.61) | TYRO3DYRK1BPDE3BPDE3AP2RY12 | |
| SCHEMBL6027523 | 0.69 | ALDH1A1 (0.46) | CDK7CDK9 | |
| SCHEMBL21514305 | 0.67 | TRPV1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539963-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND USE | Livo (Shanghai) Pharmaceutical Co., Ltd (CN) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018086593-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND USE | 礼沃（上海）医药科技有限公司 | 2018-05-17 | — | — | WO | disclosed |