Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | F2R | P25116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21362075 | 0.88 | TP53 (0.40) | CHRNA7MAPTLMNAHTTTP53 | |
| SCHEMBL20157479 | 0.86 | MAPT (0.38) | GAACHRNA7MAPTLMNAHTT | |
| SCHEMBL20157667 | 0.80 | MAPT (0.43) | GAACHRNA7MAPTLMNAHTT | |
| SCHEMBL21362803 | 0.78 | GAA (0.37) | GAACHRNA7MAPTLMNAHTT | |
| SCHEMBL21362221 | 0.78 | CXCR2 (0.39) | GAACHRNA7MAPTLMNAHTT | |
| SCHEMBL21362215 | 0.78 | KMT2A (0.41) | GAAMAPTLMNAHTTTP53 | |
| SCHEMBL20157477 | 0.77 | ALDH1A1 (0.52) | MAPTLMNAHTTTP53KMT2A | |
| SCHEMBL20158155 | 0.74 | HDAC1 (0.42) | MAPTLMNAHTTTP53KMT2A | |
| SCHEMBL21351938 | 0.72 | PTPN1 (0.42) | CHRNA7KMT2ARXRATSHRNPC1 | |
| SCHEMBL20157496 | 0.71 | HDAC1 (0.43) | MAPTHTTKMT2ARXRATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086605-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |