Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PRNP | P04156 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21362618 | 0.86 | BRD4 (0.35) | BRD4RXFP1MAPTMAPK14TP53 | |
| SCHEMBL21352162 | 0.78 | BRD4 (0.32) | BRD4MAPK14 | |
| SCHEMBL21362087 | 0.73 | BRD4 (0.32) | BRD4MAPK14 | |
| SCHEMBL21362208 | 0.72 | BRD4 (0.36) | BRD4 | |
| SCHEMBL21362620 | 0.71 | BRD4 (0.38) | BRD4 | |
| SCHEMBL21362086 | 0.71 | BRD4 (0.34) | BRD4MAPK14CNR2 | |
| SCHEMBL20158149 | 0.70 | GRM5 (0.33) | BRD4MAPTMAPK14TP53 | |
| SCHEMBL21352227 | 0.70 | BRD4 (0.32) | BRD4MAPK14 | |
| SCHEMBL21351950 | 0.70 | BRD4 (0.35) | BRD4MAPTMAPK14THRB | |
| SCHEMBL21352234 | 0.69 | BRD4 (0.32) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086605-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |