Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.56 |
| ▸ | ITGB6 | P18564 | 17/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.56 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.51 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.51 |
| ▸ | ITGB8 | P26012 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158252 | 0.88 | ITGAV (0.56) | ITGAVITGB6ITGB3ITGB1ITGB5 | |
| SCHEMBL23747280 | 0.88 | ITGAV (0.70) | ITGAVITGB6ITGB3 | |
| SCHEMBL23747282 | 0.87 | ITGAV (0.63) | ITGAVITGB6ITGB3 | |
| SCHEMBL19399826 | 0.80 | ITGB3 (0.67) | ITGAVITGB3ITGB1ITGB5 | |
| SCHEMBL21317478 | 0.79 | ITGAV (0.65) | ITGAVITGB6ITGB3ITGB1ITGB5 | |
| SCHEMBL20158235 | 0.78 | ITGAV (0.68) | ITGAVITGB6ITGB3 | |
| SCHEMBL21317515 | 0.78 | ITGAV (0.61) | ITGAVITGB6ITGB3ITGB1ITGB5 | |
| SCHEMBL20141731 | 0.78 | ITGAV (0.67) | ITGAVITGB6ITGB3 | |
| SCHEMBL20141734 | 0.78 | ITGAV (0.67) | ITGAVITGB6ITGB3 | |
| SCHEMBL30487512 | 0.77 | ITGAV (0.61) | ITGAVITGB6ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089355-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |