Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18630001 | 0.82 | DPP4 (0.33) | DPP4FAPDPP8DPP9HDAC1 | |
| SCHEMBL13654392 | 0.82 | PIK3CA (0.38) | DPP4FAPDPP8DPP9HDAC1 | |
| SCHEMBL256350 | 0.77 | CYP3A4 (0.37) | DPP4FAPDPP8DPP9HDAC1 | |
| SCHEMBL28642560 | 0.75 | HDAC1 (0.36) | DPP4FAPDPP8DPP9HDAC1 | |
| SCHEMBL4753742 | 0.72 | HDAC1 (0.48) | DPP4FAPDPP8DPP9HDAC1 | |
| SCHEMBL29710053 | 0.71 | CTSL (0.41) | DPP4FAPDPP8DPP9HDAC1 | |
| SCHEMBL30838602 | 0.71 | HDAC1 (0.47) | DPP4FAPDPP8DPP9HDAC1 | |
| SCHEMBL13322627 | 0.71 | DPP4 (0.35) | DPP4FAPDPP8DPP9HDAC1 | |
| SCHEMBL8217044 | 0.71 | NAMPT (0.37) | DPP4FAPDPP8DPP9HDAC1 | |
| SCHEMBL1721216 | 0.69 | HDAC1 (0.46) | DPP4FAPDPP8DPP9HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |