Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.63 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.63 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.63 |
| ▸ | TACR3 | P29371 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159152 | 0.92 | MTOR (0.65) | MTORRPTORMLST8TACR3DRD4 | |
| SCHEMBL20159156 | 0.91 | MTOR (0.64) | MTORRPTORMLST8TACR3DRD4 | |
| SCHEMBL20159110 | 0.91 | MTOR (0.57) | MTORRPTORMLST8GRM5DRD2 | |
| SCHEMBL20158990 | 0.90 | MTOR (0.77) | MTORRPTORMLST8 | |
| SCHEMBL20159160 | 0.89 | MTOR (0.61) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20159082 | 0.88 | MTOR (0.75) | MTORRPTORMLST8TACR3DRD4 | |
| SCHEMBL20159090 | 0.87 | MTOR (0.71) | MTORRPTORMLST8TACR3DRD4 | |
| SCHEMBL20158993 | 0.87 | MTOR (0.64) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20159131 | 0.85 | MTOR (0.65) | MTORRPTORMLST8TACR3DRD4 | |
| SCHEMBL20158989 | 0.85 | MTOR (0.72) | MTORRPTORMLST8DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |