Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.57 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.57 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.57 |
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159158 | 0.91 | MTOR (0.63) | MTORRPTORMLST8GRM5DRD2 | |
| SCHEMBL20158993 | 0.89 | MTOR (0.64) | MTORRPTORMLST8HTR7DRD2 | |
| SCHEMBL20159267 | 0.89 | MTOR (0.56) | MTORRPTORMLST8HTR7DRD2 | |
| SCHEMBL20159030 | 0.87 | MTOR (0.62) | MTORRPTORMLST8HTR7DRD2 | |
| SCHEMBL20139236 | 0.85 | MTOR (0.68) | MTORRPTORMLST8HTR7ALDH1A1 | |
| SCHEMBL20159112 | 0.84 | MTOR (0.58) | MTORRPTORMLST8HTR7ALDH1A1 | |
| SCHEMBL20140555 | 0.84 | MTOR (0.78) | MTORRPTORMLST8HTR7DRD2 | |
| SCHEMBL20159019 | 0.82 | MTOR (0.59) | MTORRPTORMLST8HTR7DRD2 | |
| SCHEMBL20159231 | 0.82 | MTOR (0.68) | MTORRPTORMLST8HSD17B10HTR7 | |
| SCHEMBL20159152 | 0.82 | MTOR (0.65) | MTORRPTORMLST8HSD17B10DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |