Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 6/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | CTSE | P14091 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 3/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159417 | 1.00 | PDE3A (0.37) | PDE3APDE3BCNR1CNR2CTSD | |
| SCHEMBL20159422 | 1.00 | PDE3A (0.37) | PDE3APDE3BCNR1CNR2CTSD | |
| SCHEMBL20159430 | 0.92 | PDE4B (0.38) | PDE3APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL20143661 | 0.81 | CD274 (0.45) | PDE3APDE3BPDE4DPIK3CAMTOR | |
| SCHEMBL20142921 | 0.80 | PDE4B (0.40) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL20159213 | 0.80 | PDE4A (0.40) | PDE3APDE3BCTSEBACE1PDE4B | |
| SCHEMBL20138907 | 0.80 | PDE4A (0.40) | PDE3APDE3BCTSEBACE1PDE4B | |
| SCHEMBL20142922 | 0.80 | PDE4A (0.40) | PDE3APDE3BCTSEBACE1PDE4B | |
| SCHEMBL25095015 | 0.79 | PDE4B (0.37) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL20159108 | 0.77 | PDE4B (0.38) | PDE3APDE3BPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |