Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16730387 | 0.93 | GRM5 (0.51) | GRM5HTTHRH3LMNAITGB3 | |
| SCHEMBL25074216 | 0.92 | HTT (0.49) | GRM5HTTHRH3LMNAITGB3 | |
| SCHEMBL21569675 | 0.86 | GRM5 (0.43) | GRM5HTTHRH3LMNAITGB3 | |
| SCHEMBL25571575 | 0.86 | GRM5 (0.47) | GRM5HTTHRH3LMNAITGB3 | |
| SCHEMBL24747258 | 0.86 | GRM5 (0.56) | GRM5HTTHRH3LMNAITGB3 | |
| SCHEMBL20159545 | 0.86 | GRM5 (0.45) | GRM5HTTHRH3LMNAITGB3 | |
| SCHEMBL18713240 | 0.81 | HTT (0.51) | GRM5HTTHRH3LMNAHSD11B1 | |
| SCHEMBL15417790 | 0.79 | HTT (0.46) | GRM5HTTLMNAITGB3ITGA2B | |
| SCHEMBL19158899 | 0.78 | GRM5 (0.62) | GRM5HTTHRH3ITGB3ITGA2B | |
| SCHEMBL26159927 | 0.78 | GRM5 (0.39) | GRM5HTTHRH3LMNAHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089695-A1 | TOLL-LIKE RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USE | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2018-05-17 | — | — | WO | disclosed |