Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18713240 | 0.91 | HTT (0.51) | GRM5HTTHRH3LMNAHPGD | |
| SCHEMBL16730387 | 0.89 | GRM5 (0.51) | GRM5HTTHRH3LMNAHPGD | |
| SCHEMBL19158899 | 0.89 | GRM5 (0.62) | GRM5HTTHRH3HPGDITGB3 | |
| SCHEMBL20159548 | 0.86 | GRM5 (0.49) | GRM5HTTHRH3LMNAHPGD | |
| SCHEMBL25571575 | 0.86 | GRM5 (0.47) | GRM5HTTHRH3LMNAHPGD | |
| SCHEMBL12683549 | 0.85 | GRM5 (0.69) | GRM5HTTHRH3HPGDITGB3 | |
| SCHEMBL18713241 | 0.84 | GRM5 (0.58) | GRM5HTTHRH3LMNAHPGD | |
| SCHEMBL18390027 | 0.84 | LMNA (0.56) | GRM5HTTLMNAHPGDITGB3 | |
| SCHEMBL18713235 | 0.83 | LMNA (0.58) | GRM5HTTLMNAHPGDITGB3 | |
| SCHEMBL20159545 | 0.82 | GRM5 (0.45) | GRM5HTTHRH3LMNAITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |