Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CTSA | P10619 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | SCNN1A | P37088 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | THPO | P40225 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12635762 | 0.99 | LMNA (0.43) | LMNACTSAGRM5SCNN1AALDH1A1 | |
| Iodide SCHEMBL2051325 | 0.88 | SCNN1A (0.45) | LMNACTSAGRM5SCNN1AALDH1A1 | |
| Iodide SCHEMBL2016298 | 0.88 | MEN1 (0.41) | LMNACTSAGRM5SCNN1AALDH1A1 | |
| SCHEMBL12636313 | 0.87 | MEN1 (0.41) | LMNACTSAGRM5SCNN1AALDH1A1 | |
| SCHEMBL12636316 | 0.87 | SCNN1A (0.45) | LMNACTSAGRM5SCNN1AALDH1A1 | |
| Iodide SCHEMBL2015549 | 0.86 | SCNN1A (0.39) | LMNACTSAGRM5SCNN1AALDH1A1 | |
| SCHEMBL12634871 | 0.85 | GRM5 (0.43) | LMNACTSAGRM5SCNN1AALDH1A1 | |
| SCHEMBL12635944 | 0.85 | SCNN1A (0.39) | LMNACTSAGRM5SCNN1AALDH1A1 | |
| Iodide SCHEMBL2014861 | 0.85 | GRM5 (0.37) | LMNACTSAGRM5SCNN1AALDH1A1 | |
| Iodide SCHEMBL2016400 | 0.84 | CTSA (0.37) | LMNACTSAGRM5SCNN1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | claimed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |