Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 4/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138690 | 0.80 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20138672 | 0.80 | PSEN1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20159967 | 0.78 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20140248 | 0.77 | F10 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20138683 | 0.71 | — | — | |
| SCHEMBL20138803 | 0.71 | SCN4A (0.38) | — | |
| SCHEMBL20142991 | 0.71 | MAPT (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20138797 | 0.70 | KDR (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20138682 | 0.69 | PTGS2 (0.36) | — | |
| SCHEMBL20142944 | 0.68 | AR (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538516-B1 | PHENOXYTRIAZOLES | HOFFMANN LA ROCHE (CH) | 2021-06-16 | — | — | EP | disclosed |
| WO-2018087018-A1 | PHENOXYTRIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-17 | — | — | WO | disclosed |